The world of cell sorting has always posed challenges, particularly when dealing with delicate cardiomyocyte samples. Traditional methods often result in cell damage or loss due to the harsh conditions in which they operate. But what if you could sort these vital cells without sacrificing their viability or functionality? Enter the Nodexus NX One MAX, our state-of-the-art, gentle benchtop sorter that is transforming cardiomyocyte sorting for the first time.

The Challenges of Cardiomyocyte Sorting

Historically, sorting cardiomyocytes has been a daunting task primarily due to the fragility of these cells. Cardiomyocytes, crucial for research in cardiac diseases and therapies, tend to fragment or lose viability under the pressure and electrostatic forces applied by conventional flow cytometers and electrostatic sorters. These traditional technologies, which often operate using high-pressure systems, can inadvertently alter the cells’ morphology and functionality, compromising experimental outcomes.

Why Traditional Sorters Fall Short

1. High Pressure: Traditional sorters often operate above 20 psi, which can tear apart sensitive cardiomyocyte structures.
2. Electrostatic Damage: Electrostatically induced damage can lead to metabolic disruptions within cells, affecting their viability.
3. Gene Expression Alterations: Harsh sorting conditions can alter gene expression profiles, leading to inaccurate experimental data.
4. Reproducibility Issues: Variability in cell health post-sorting can render experimental data unreliable.

For researchers, the quest has been to find a method that maintains cell integrity while delivering high-performance results. Nodexus provides the solution with the NX One MAX, designed with precision to address these challenges head-on.

The NX One MAX: A Gentle Revolution

Our NX One MAX is a game-changer in the field of cell sorting, specifically catering to the unique needs of cardiomyocyte research. The platform’s innovative microfluidic technology ensures gentle cell handling, preserving cellular structure and function.

Key Features of the NX One MAX

• Ultra-Low Pressure: Operating at less than 0.1 psi, the NX One MAX eliminates the risk of pressure-induced cell damage, maintaining high viability for cardiomyocyte samples.
• Microfluidic Precision: By leveraging microfluidic technology, the platform facilitates contamination-free, precise sorting, minimizing biohazard waste and preventing aerosol generation.
• Wide Range Capacity: Capable of sorting cardiomyocytes and other cells ranging from 2 to 60 μm in diameter, the NX One MAX offers flexibility for various experimental setups.

Enhancing Cardiomyocyte Research with NX One MAX

With the NX One MAX, researchers now have access to an advanced toolset that not only improves the sorting process but also enhances the overall quality of cardiomyocyte-based research:

1. High Viability and Purity: Cells sorted using the NX One MAX retain their viability and purity, crucial for downstream applications like drug testing or gene editing.
2. Sterility and Contamination Control: The closed system design ensures sterility, reducing contamination risks in experiments with long-term cultures.
3. Increased Throughput: The ability to sort into microtiter plates of varying sizes enhances experimental throughput and efficiency.

Transforming Experimental Outcomes

The benefits of using the NX One MAX go beyond just sorting. By ensuring higher viability and preserving cell integrity, the data derived from sorted samples is more reliable, reducing variability and supporting more accurate research conclusions.

Real-World Applications

• Regenerative Medicine: With its gentle sorting capabilities, the NX One MAX is ideal for applications in regenerative medicine where preserving cell fate and functionality is critical.
• Drug Discovery: By maintaining the health and viability of cardiomyocytes, the NX One MAX minimizes variables in drug screening processes, leading to faster and more reliable therapeutic discoveries.
• CRISPR and Gene Editing: The platform supports precise enrichment of genetically modified populations, a vital step in CRISPR workflows.

A Seamless Integration

One of the strong suits of the NX One MAX is its adaptability and ease of use. Designed to fit seamlessly into any laboratory environment, its compact design allows operation on the benchtop or from within a biosafety cabinet, without requiring specialized infrastructure or training.

Ready to Upgrade Your Lab?

As we push the boundaries of cardiomyocyte research, the NX One MAX offers you the unprecedented opportunity to enhance the scope and reliability of your experiments. Whether you’re delving into drug discovery, regenerative medicine, or advanced cell therapies, our platform paves the way for innovation and precision.

For more information on how the NX One MAX can elevate your research, visit our NX One MAX product page and request a demo. Join us in revolutionizing cardiomyocyte sorting and take your research to new heights.

Embrace the gentle power of the NX One MAX and see what you can achieve.