Explore our Application Notes & mammalian and non-mammalian library which highlight examples of the Nodexus NX One instrument, consumables, and software.

The NX One simplifies the complexities of single-cell sorting and dispensing at a price anyone can afford.

Application Notes

Plug-and-Play Sorting for Large Particles: 60μm and Beyond

Size-based particle analysis and sorting are crucial in biological applications as the function, origin, or type of biological particles can be traced using cell size as a metric. For traditional fluorescence-activated cell sorting systems, processing large (>30 μm diameter) particles or heterogeneous

Neuronal Patterning of NX One Sorted Pluripotent Monoclonal iPSCs

Human Induced Pluripotent Stem Cells (hiPSCs) are immensely valuable in research and drug discovery. These cells offer a unique platform to study disease mechanisms, model patient-specific conditions, screen potential drug candidates, and test the efficiency of gene editing strategies like CRISPR. Obtaining monoclonal iPSC lines thus becomes crucial

Gentle, Efficient, and Reproducible Single Cell Sorting of Human iPSCs

Human induced pluripotent stem cells (iPSCs) hold immense significance and potential in regenerative medicine and disease modeling. These cells, derived from adult somatic cells like the skin or blood cells, can be reprogrammed to revert to a pluripotent state, which enables them to differentiate into any cell type in the human body (Mahajani et al., 2019)

Highly Efficient, Gentle, and Contamination-Free Single Cell Sorting

Single-cell sorting is a critical technique in biological and medical research, enabling scientists to isolate and study specific cell populations precisely [1]. While traditional cell sorting methods have been effective, there is an increasing recognition of the importance of sorting one cell per well using a gentle sorting system when sorting single cells

Expression-Based Cell Line Development

The cell line development process is essential for biomedical and basic research as it broadly contributes to the efficiency, quality, and consistency of experimental outcomes, e.g., newer therapeutic approaches such as gene therapy require the development of monoclonal cell lines to test the efficacy and toxicity of viral vector transduction

Repeatability, Reproducibility, and Uniformity Across Units

Reliable success in single-cell clonogenesis depends on the ability to consistently deposit a single cell in a single well across multiple experimental runs while ensuring consistency across instruments and different instrument operators

Sample Library

Chinese Hamster Ovary (CHO)
iHEP & other Hepatocytes
iPSC (wild type and Parkinson’s-derived)
Primary Human Skeletal Muscle Cells
Nascent Organoids
Nannochloropsis Algae
Bacteria (E. coli)

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